| 408 | Houston at Tulsa | 2021-10-01 16:30:00 | Houston 3.5 points 160 moneyline | Tulsa -3.5 points -165 moneyline | Over 56.5 Under 57.0 |
| 438 | Memphis at Temple | 2021-10-02 10:00:00 | Memphis -11.0 points -440 moneyline | Temple 11.5 points 360 moneyline | Over 61.0 Under 61.5 |
| 453 | South Florida at Southern Methodist | 2021-10-02 10:00:00 | South Florida 20.5 points 900 moneyline | Southern Methodist -20.5 points -1000 moneyline | Over 68.0 Under 69.5 |
| 462 | Tulane at East Carolina | 2021-10-02 10:00:00 | Tulane -3.5 points -160 moneyline | East Carolina 3.5 points 160 moneyline | Over 63.0 Under 64.5 |
| 423 | Cincinnati at Notre Dame | 2021-10-02 11:30:00 | Cincinnati -2.5 points -130 moneyline | Notre Dame 2.5 points 117 moneyline | O/U 51.0 |
| 420 | Central Florida at Navy | 2021-10-02 12:30:00 | Central Florida -15.0 points -660 moneyline | Navy 15.5 points 500 moneyline | Over 55.5 Under 56.5 |
| 406 | Virginia at Miami (FL) | 2021-09-30 16:30:00 | Virginia 3.5 points 155 moneyline | Miami (FL) -3.5 points -155 moneyline | O/U 62.0 |
| 409 | Iowa at Maryland | 2021-10-01 17:00:00 | Iowa -3.5 points -156 moneyline | Maryland 3.5 points 140 moneyline | Over 45.5 Under 46.5 |
| 407 | Brigham Young at Utah State | 2021-10-01 18:00:00 | Brigham Young -8.5 points -330 moneyline | Utah State 9.0 points 300 moneyline | O/U 58.5 |
| 433 | Louisiana at South Alabama | 2021-10-02 10:00:00 | Louisiana -11.0 points -400 moneyline | South Alabama 11.5 points 350 moneyline | Over 51.0 Under 51.5 |
| 434 | Louisiana Tech at North Carolina State | 2021-10-02 10:00:00 | Louisiana Tech 19.5 points 760 moneyline | North Carolina State -18.5 points -1060 moneyline | Over 54.5 Under 55.5 |
| 435 | Louisiana-Monroe at Coastal Carolina | 2021-10-02 10:00:00 | Louisiana-Monroe 34.5 points 2500 moneyline | Coastal Carolina -32.5 points -10000 moneyline | Over 58.5 Under 59.5 |
| 436 | Louisville at Wake Forest | 2021-10-02 10:00:00 | Louisville 7.0 points 225 moneyline | Wake Forest -7.0 points -244 moneyline | O/U 60.5 |
| 437 | Marshall at Middle Tennessee State | 2021-10-02 10:00:00 | Marshall -10.0 points -385 moneyline | Middle Tennessee State 10.0 points 340 moneyline | O/U 64.5 |
| 439 | Michigan at Wisconsin | 2021-10-02 10:00:00 | Michigan 1.0 points 102 moneyline | Wisconsin 1.0 points -105 moneyline | O/U 43.5 |
| 440 | Minnesota at Purdue | 2021-10-02 10:00:00 | Minnesota 2.5 points 110 moneyline | Purdue -2.0 points -130 moneyline | O/U 47.5 |
| 441 | Mississippi at Alabama | 2021-10-02 10:00:00 | Mississippi 14.5 points 460 moneyline | Alabama -14.5 points -500 moneyline | Over 76.5 Under 77.5 |
| 442 | Mississippi State at Texas A&M | 2021-10-02 10:00:00 | Mississippi State 9.5 points 300 moneyline | Texas A&M -9.5 points -355 moneyline | Over 45.5 Under 46.5 |
| 443 | Nevada at Boise State | 2021-10-02 10:00:00 | Nevada 6.5 points 210 moneyline | Boise State -6.5 points -240 moneyline | Over 56.0 Under 57.5 |
| 444 | Nevada-Las Vegas at Texas-San Antonio | 2021-10-02 10:00:00 | Nevada-Las Vegas 20.5 points 800 moneyline | Texas-San Antonio -20.0 points -1250 moneyline | Over 56.5 Under 57.0 |
| 445 | New Mexico State at San Jose State | 2021-10-02 10:00:00 | New Mexico State 27.5 points 1600 moneyline | San Jose State -27.5 points -6000 moneyline | Over 51.5 Under 52.5 |
| 446 | Northwestern at Nebraska | 2021-10-02 10:00:00 | Northwestern 10.0 points 340 moneyline | Nebraska -10.0 points -380 moneyline | O/U 50.0 |
| 447 | Ohio at Akron | 2021-10-02 10:00:00 | Ohio -9.5 points -370 moneyline | Akron 10.0 points 310 moneyline | O/U 54.5 |
| 448 | Ohio State at Rutgers | 2021-10-02 10:00:00 | Ohio State -15.5 points -670 moneyline | Rutgers 15.5 points 500 moneyline | O/U 56.5 |
| 449 | Oklahoma at Kansas State | 2021-10-02 10:00:00 | Oklahoma -10.5 points -400 moneyline | Kansas State 10.5 points 350 moneyline | Over 51.5 Under 52.5 |
| 450 | Old Dominion at Texas-El Paso | 2021-10-02 10:00:00 | Old Dominion 4.5 points 165 moneyline | Texas-El Paso -3.5 points -175 moneyline | O/U 49.5 |
| 451 | Oregon at Stanford | 2021-10-02 10:00:00 | Oregon -7.0 points -286 moneyline | Stanford 7.5 points 245 moneyline | Over 58.0 Under 59.0 |
| 452 | Pittsburgh at Georgia Tech | 2021-10-02 10:00:00 | Pittsburgh -3.0 points -150 moneyline | Georgia Tech 3.5 points 135 moneyline | Over 57.0 Under 57.5 |
| 454 | Southern California at Colorado | 2021-10-02 10:00:00 | Southern California -7.0 points -260 moneyline | Colorado 7.0 points 235 moneyline | Over 50.0 Under 51.0 |
| 455 | Southern Mississippi at Rice | 2021-10-02 10:00:00 | Southern Mississippi 3.0 points 128 moneyline | Rice -2.5 points -140 moneyline | Over 44.5 Under 45.5 |
| 456 | Syracuse at Florida State | 2021-10-02 10:00:00 | Syracuse 4.5 points 172 moneyline | Florida State -4.5 points -190 moneyline | Over 51.5 Under 52.0 |
| 457 | Tennessee at Missouri | 2021-10-02 10:00:00 | Tennessee 3.5 points 140 moneyline | Missouri -3.0 points -155 moneyline | O/U 63.0 |
| 458 | Texas at Texas Christian | 2021-10-02 10:00:00 | Texas -4.0 points -180 moneyline | Texas Christian 4.5 points 165 moneyline | Over 66.5 Under 67.5 |
| 459 | Texas Tech at West Virginia | 2021-10-02 10:00:00 | Texas Tech 7.5 points 260 moneyline | West Virginia -7.0 points -290 moneyline | Over 56.0 Under 57.5 |
| 460 | Toledo at Massachusetts | 2021-10-02 10:00:00 | Toledo -26.0 points -3200 moneyline | Massachusetts 26.5 points 1600 moneyline | Over 58.0 Under 58.5 |
| 461 | Troy at South Carolina | 2021-10-02 10:00:00 | Troy 7.0 points 235 moneyline | South Carolina -7.0 points -275 moneyline | Over 44.0 Under 45.0 |
| 463 | Washington at Oregon State | 2021-10-02 10:00:00 | Washington -2.5 points -152 moneyline | Oregon State 2.5 points 120 moneyline | Over 54.5 Under 55.0 |
| 464 | Washington State at California | 2021-10-02 10:00:00 | Washington State 7.5 points 255 moneyline | California -7.5 points -286 moneyline | Over 52.0 Under 52.5 |
| 465 | Western Kentucky at Michigan State | 2021-10-02 10:00:00 | Western Kentucky 10.5 points 333 moneyline | Michigan State -10.0 points -357 moneyline | Over 59.0 Under 60.5 |
| 466 | Western Michigan at Buffalo | 2021-10-02 10:00:00 | Western Michigan -5.5 points -210 moneyline | Buffalo 6.5 points 190 moneyline | Over 58.5 Under 59.0 |
| 410 | Air Force at New Mexico | 2021-10-02 10:00:00 | Air Force -10.5 points -400 moneyline | New Mexico 10.5 points 350 moneyline | Over 48.5 Under 49.0 |
| 411 | Appalachian State at Georgia State | 2021-10-02 10:00:00 | Appalachian State -10.0 points -380 moneyline | Georgia State 10.0 points 340 moneyline | Over 55.5 Under 56.0 |
| 412 | Arizona State at UCLA | 2021-10-02 10:00:00 | Arizona State 3.5 points 150 moneyline | UCLA -3.5 points -165 moneyline | O/U 55.0 |
| 413 | Arkansas at Georgia | 2021-10-02 10:00:00 | Arkansas 18.5 points 950 moneyline | Georgia -18.0 points -1010 moneyline | O/U 48.5 |
| 414 | Arkansas State at Georgia Southern | 2021-10-02 10:00:00 | Arkansas State 2.5 points 108 moneyline | Georgia Southern -1.5 points -120 moneyline | O/U 65.0 |
| 415 | Army at Ball State | 2021-10-02 10:00:00 | Army -6.0 points -225 moneyline | Ball State 6.5 points 210 moneyline | Over 46.5 Under 47.5 |
| 416 | Auburn at Louisiana State | 2021-10-02 10:00:00 | Auburn 3.5 points 165 moneyline | Louisiana State -3.5 points -180 moneyline | O/U 54.5 |
| 417 | Baylor at Oklahoma State | 2021-10-02 10:00:00 | Baylor 4.0 points 165 moneyline | Oklahoma State -3.5 points -189 moneyline | O/U 49.5 |
| 418 | Boston College at Clemson | 2021-10-02 10:00:00 | Boston College 16.0 points 650 moneyline | Clemson -14.5 points -750 moneyline | Over 47.0 Under 47.5 |
| 419 | Bowling Green State at Kent State | 2021-10-02 10:00:00 | Bowling Green State 16.5 points 600 moneyline | Kent State -15.5 points -800 moneyline | Over 55.0 Under 56.5 |
| 421 | Central Michigan at Miami (OH) | 2021-10-02 10:00:00 | Central Michigan 1.0 points 100 moneyline | Miami (OH) -1.0 points -114 moneyline | Over 55.5 Under 56.5 |
| 422 | Charlotte at Illinois | 2021-10-02 10:00:00 | Charlotte 10.0 points 310 moneyline | Illinois -10.0 points -335 moneyline | O/U 54.5 |
| 424 | Connecticut at Vanderbilt | 2021-10-02 10:00:00 | Connecticut 14.5 points 500 moneyline | Vanderbilt -14.5 points -640 moneyline | O/U 52.0 |
| 425 | Duke at North Carolina | 2021-10-02 10:00:00 | Duke 18.0 points 680 moneyline | North Carolina -17.5 points -850 moneyline | Over 69.5 Under 70.0 |
| 426 | Eastern Michigan at Northern Illinois | 2021-10-02 10:00:00 | Eastern Michigan -1.0 points 100 moneyline | Northern Illinois 1.0 points -105 moneyline | Over 63.0 Under 63.5 |
| 427 | Florida at Kentucky | 2021-10-02 10:00:00 | Florida -8.0 points -303 moneyline | Kentucky 8.5 points 270 moneyline | Over 55.0 Under 55.5 |
| 428 | Florida International at Florida Atlantic | 2021-10-02 10:00:00 | Florida International 11.0 points 350 moneyline | Florida Atlantic -10.5 points -420 moneyline | O/U 51.5 |
| 430 | Indiana at Penn State | 2021-10-02 10:00:00 | Indiana 11.5 points 375 moneyline | Penn State -10.5 points -435 moneyline | Over 51.5 Under 52.5 |
| 431 | Kansas at Iowa State | 2021-10-02 10:00:00 | Kansas 33.5 points 2500 moneyline | Iowa State -32.5 points -10000 moneyline | Over 57.5 Under 58.5 |
| 432 | Liberty at Alabama-Birmingham | 2021-10-02 16:00:00 | Liberty 2.0 points 110 moneyline | Alabama-Birmingham -1.0 points -120 moneyline | Over 49.5 Under 50.0 |
| 429 | Fresno State at Hawaii | 2021-10-02 20:00:00 | Fresno State -10.0 points -400 moneyline | Hawaii 10.5 points 310 moneyline | O/U 63.0 |
